By Do K.-A., Qin Z.S., Vannucci M. (eds.)
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Extra resources for Advances in Statistical Bioinformatics: Models and Integrative Inference for High-Throughput Data
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4 Bisulfite conversion. Reprinted with permission from Zilberman D and Henikoff S. Genome-wide analysis of DNA methylation patterns. Development 2007;134:3959. (See color plate). are treated with sodium bisulfate. 4). With earlier sequencing technologies, such as microarrays, the analysis of bisulfate-treated DNA was extremely cumbersome, but it is very well suited to single-molecule, NGS technologies (Laird, 2010). BS-Seq remains, however, a complex process. Methylation occurs differently on each strand of DNA, so four strands must be analyzed: each bisulfite-treated strand and two reference strands.
Advances in Statistical Bioinformatics: Models and Integrative Inference for High-Throughput Data by Do K.-A., Qin Z.S., Vannucci M. (eds.)