Analysis of Microarray Gene Expression Data by Mei-Ling Ting Lee PDF

By Mei-Ling Ting Lee

ISBN-10: 1402077882

ISBN-13: 9781402077883

After genomic sequencing, microarray expertise has emerged as a known platform for genomic reviews within the existence sciences. Microarray expertise presents a scientific method to survey DNA and RNA edition. With the abundance of information made out of microarray stories, besides the fact that, the final word influence of the experiences on biology will count seriously on info mining and statistical research. The contribution of this ebook is to supply readers with an built-in presentation of varied subject matters on reading microarray data.

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Extra resources for Analysis of Microarray Gene Expression Data

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In the genes of many eukaryotes, the protein-encoding sequence is interrupted by varying numbers of segments called introns. The coding sequence segments interrupted by the introns are called exons. Introns are re­ moved in the splicing process to generate the final mature mRNA ready to be translated by the protein synthesis machinery. 5. The Genetic Code The sequence of nucleotides in DNA is important not because of its structure, but because it codes for the sequence of amino acids that dictate the structure of a protein with a defined function, be it struc­ tural or catalytic.

If similarities exist between probes on the same microarray, they can cross-hybridize to more than one gene target, making the results hard to analyze. Third, all oligonucleotides must have similar hybridization properties. Usually all the probes are designed so that their melting temperature is within 1-2 degrees Cel­ sius and that they have a similar content of G and C nucleotide base pairs. Several probe selection algorithms have been developed, but so far no consensus exists on the most effective design principles.

These matching base pairs are referred to as complementary. For example, a short segment with ten nucleotides might be of the form 10 ANALYSIS OF MICROARRAY GENE EXPRESSION DATA The specific base pairing of DNA is the mechanism by which encoded information can be transferred from generation to generation with very little alteration. When the DNA is copied by the processes of replication and transcription, the double helical structure of the DNA is opened up and a copy is made based on the specificity of the base pairing.

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Analysis of Microarray Gene Expression Data by Mei-Ling Ting Lee

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