By M. A. D. van Zoelen, A. Achouiti, T. van der Poll (auth.), Prof. Jean-Louis Vincent (eds.)
The Annual replace compiles the latest advancements in experimental and medical examine and perform in a single accomplished reference booklet. The chapters are written via good well-known specialists within the box of extensive care and emergency drugs. it really is addressed to every person concerned about inner drugs, anesthesia, surgical procedure, pediatrics, extensive care and emergency medicine.
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Extra resources for Annual Update in Intensive Care and Emergency Medicine 2011
The most frequently used cannabinoid ligands are agonists (including endogenous agonists) and inverse agonists (Table 1). Inverse agonists exert opposite pharmacological effects to those of a receptor agonist [4 – 6]. Endocannabinoids are endogenous arachidonate derivatives. The two most well characterized endocannabinoids are AEA and 2-arachidonoyl glycerol (2AG), both of which are fatty acid amides (FAAs). In addition, N-arachidonoyldopamine (NADA) has also been shown to behave as a cannabimimetic compound , although its pharmacology is as yet poorly understood.
In addition, N-arachidonoyldopamine (NADA) has also been shown to behave as a cannabimimetic compound , although its pharmacology is as yet poorly understood. , they may potentiate the activity of AEA or 2-AG at their receptors by inhibiting their degradation . The actions Table 1. Cannabinoid ligands Agonists CB1R/CB2R ‘Classical’ cannabinoids ) Δ9 – THC – partial agonist – efficacy CB1>CB2 ) HU 2010 – high CB1R/CB2R affinity – full CB1R/CB2R agonist CB2R selective ‘Classical’ cannabinoid ) JWH-133 Aminoalkylindoles ) WIN55212 – 2 Inverse agonists CB1R selective Diarylpyrazoles ) SR 141716A ) AM251 CB2R selective Diarylpyrazoles ) SR 144528 ) AM 630 Endogenous agonists ) Anandamide (AEA) – moderate CB1R>CB2R affinity – partial agonist, efficacy CB1R> CB2R ) 2-Arachidonoylglycerol (2AG) – moderate CB1R/CB2R affinity – high CB1R/CB2R efficacy 17 I 18 I C.
J Pharmacol Exp Ther 330: 902 – 910 16. Bisogno T, Howell F, Williams G, et al (2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol 163: 463 – 468 17. De Petrocellis L, Di Marzo V (2009) An introduction to the endocannabinoid system: from the early to the latest concepts. Best Pract Res Clin Endocrinol Metab 23: 1 – 15 18. Di Pasquale E, Chahinian H, Sanchez P, Fantini J (2009) The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent.
Annual Update in Intensive Care and Emergency Medicine 2011 by M. A. D. van Zoelen, A. Achouiti, T. van der Poll (auth.), Prof. Jean-Louis Vincent (eds.)